Protease (from A. oryzae)

-Amylase: a major digestive enzyme that is essential for the digestion of long-chain polysaccharides.

-Protease: the enzyme responsible for the breakdown of peptide bonds that releases individual amino acids from complex proteins.

-Glucoamylase: a digestive enzyme that breaks down carbohydrates into glucose.

-Invertase: breaks down sucrose into fructose and glucose.

-Lipase: the enzyme responsible for the digestion of fats.

Digestase contains two sources of protease and three different sources of lipase to broaden activity and ensure viability under a variety of pH profiles.

Using a new technology that replicates the human stomach and small intestines, the efficacy of Digestase as a digestive aid was assessed. Digestase supplementation improved the following digestive processes:

Under normal digestive conditions: Digestase more than doubled the absorption of carbohydrates and increased the absorption of protein in the ileum while protein absorption remained essentially the same in the jejunum.

Under impaired digestive conditions: differences were even greater: glucose absorption in the jejunum increasing 9-fold and protein digestion increasing significantly in both the jejunum and ileum.

The health benefits of enzyme supplementation are not limited to the absorption of nutrients. Supplemental enzymes relieve digestive organs. Animal experiments are clear: enzyme supplementation results in a healthier intestinal brush border and better nutrient accretion.

Supplemental enzymes also reduce inflammation and speed up recovery. Studies in athletes have shown improved recovery time when supplementing with enzymes. Similarly, patients undergoing surgery recover more quickly if they are prescribed enzymes.

Enzymes facilitate chemical reactions, improve digestion, support digestive organs and hasten recovery. For the first time, a digestive enzyme has been tested and shown to support digestion. Digestase is AOR's newest enzyme formula and the world's first digestive enzyme supported by research.

References

· Ritz CW, Hulet RM, Self BB, Denbow DM. Growth and intestinal morphology of male turkeys as influenced by dietary supplementation of amylase and xylanase. Poult Sci. 1995 Aug;74(8):1329-34.

· Miller PC, Bailey SP, Barnes ME, Derr SJ, Hall EE. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci. 2004 Apr;22(4):365-72.

· Layer P, Keller J. Lipase supplementation therapy: standards, alternatives, and perspectives. Pancreas. 2003 Jan;26(1):1-7. Review.

· Meng X, Slominski BA, Guenter W. The effect of fat type, carbohydrase, and lipase addition on growth performance and nutrient utilization of young broilers fed wheat-based diets. Poult Sci. 2004 Oct;83(10):1718-27.

· Lomax E. The use of oral proteolytic enzymes in the post-lipoplasty patient. Case report (unpublished)

· Zeijdner E, Havenaar R, (200). The Fate of orally administered compounds during passage through the gastrointestinal tract simulated in a dynamic in vitro model (TIM). European pharmaceutical Contractor, Febr. Isue: 76-81

· Zeijdner E, Mohede R, I.C.M. (1999). Latest tool for screening new clinical foods. A dynamic, computer-controlled model of the human gastrointestinal tract is the most up-to-date technology for testing new foods. New World Health 199-2000: 105.a